Kazuhiro Irie Selected Research

1-hexylindolactam-V10

1/2008

Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes.

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Kazuhiro Irie Research Topics

Disease

56	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 05/2002
26	Neoplasms (Cancer) 07/2022 - 02/2002
7	Cognitive Dysfunction 01/2021 - 12/2010
4	Amyloid Plaque 11/2018 - 05/2002
4	Memory Disorders (Memory Loss) 01/2017 - 12/2011
4	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2009 - 05/2002
3	Obesity 09/2019 - 05/2011
3	Acquired Immunodeficiency Syndrome (AIDS) 04/2014 - 06/2009
2	HIV Infections (HIV Infection) 06/2022 - 06/2009
2	Dementia (Dementias) 01/2022 - 01/2011
2	Diabetes Mellitus 01/2020 - 05/2011
2	Insulin Resistance 01/2020 - 05/2011
2	Hepatocellular Carcinoma (Hepatoma) 09/2019 - 01/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 10/2012
2	Carcinoma (Carcinomatosis) 09/2010 - 01/2010
1	Shock 10/2021
1	Acute Erythroblastic Leukemia (Erythroleukemia) 03/2021
1	Insulinoma 01/2020
1	Hydrocephalus (Hydrocephaly) 01/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2017
1	Neuroblastoma 10/2015
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2015
1	Fibrosis (Cirrhosis) 10/2013
1	Gastritis 07/2012
1	Inflammation (Inflammations) 12/2011
1	Macular Degeneration (Age-Related Maculopathy) 12/2011
1	Hyperinsulinism (Hyperinsulinemia) 05/2011

Drug/Important Bio-Agent (IBA)

41	Amyloid (Amyloid Fibrils)IBA 01/2022 - 12/2004
25	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
12	Protein Kinase CIBA 07/2022 - 06/2009
10	IsoenzymesIBA 06/2022 - 01/2005
10	Amyloid beta-PeptidesIBA 05/2017 - 05/2002
8	aplysiatoxinIBA 07/2022 - 06/2009
7	Peptides (Polypeptides)IBA 01/2011 - 02/2002
6	debromoaplysiatoxinIBA 01/2021 - 06/2012
5	Biological ProductsIBA 05/2013 - 01/2005
4	bryostatin 1IBA 10/2021 - 02/2002
4	CarcinogensIBA 08/2013 - 02/2002
3	Insulin (Novolin)FDA Link 01/2020 - 05/2011
3	BryostatinsIBA 06/2012 - 06/2009
3	Superoxide DismutaseIBA 01/2012 - 01/2011
3	Phorbol EstersIBA 01/2011 - 05/2003
2	AntibodiesIBA 01/2022 - 04/2020
2	prostratinIBA 10/2021 - 06/2009
2	Pharmaceutical PreparationsIBA 03/2021 - 04/2013
2	Nucleotide AptamersIBA 10/2020 - 09/2020
2	Hydroxyl RadicalIBA 04/2017 - 10/2010
2	AntioxidantsIBA 01/2017 - 01/2011
2	Epstein-Barr virus early antigenIBA 05/2013 - 01/2012
2	SilymarinIBA 01/2013 - 01/2010
2	auraptenIBA 07/2012 - 01/2010
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 06/2012 - 02/2002
2	Protein Kinases (Protein Kinase)IBA 01/2011 - 10/2010
1	carvoneIBA 07/2022
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 03/2021
1	Methanol (Carbinol)IBA 03/2021
1	LuteolinIBA 03/2021
1	carnosolIBA 03/2021
1	Gefitinib (Iressa)FDA Link 03/2021
1	flavoneIBA 03/2021
1	cirsiliolIBA 03/2021
1	nobiletinIBA 03/2021
1	EnzymesIBA 01/2021
1	ImmunosorbentsIBA 01/2021
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2020
1	Amino Acids FDA Link 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2020
1	Lipase (Acid Lipase)FDA Link 09/2019
1	CurcuminIBA 09/2019
1	Apomorphine FDA Link 01/2018
1	FlavonoidsIBA 01/2017
1	Monoclonal AntibodiesIBA 01/2016
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2015
1	Amyloidogenic ProteinsIBA 01/2015
1	oil red OIBA 10/2013
1	Plant ExtractsIBA 10/2013
1	LipidsIBA 10/2013
1	IodineIBA 05/2013
1	BromineIBA 05/2013
1	acteosideIBA 01/2013
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2013
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2013
1	zerumboneIBA 01/2013
1	3,5-dicaffeoylquinic acidIBA 10/2012
1	LigandsIBA 06/2012
1	Superoxides (Superoxide)IBA 01/2012
1	CopperIBA 12/2011
1	Advanced Glycation End ProductsIBA 12/2011
1	ZincIBA 12/2011
1	N(6)-carboxymethyllysine (carboxymethyllysine)IBA 12/2011
1	Insulin ReceptorIBA 05/2011
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2011
1	Messenger RNA (mRNA)IBA 09/2010
1	Conditioned Culture MediaIBA 09/2010

Therapy/Procedure

7	Therapeutics 10/2021 - 05/2012
1	Kampo Medicine (Kampo) 01/2022
1	Intravenous Administration 01/2017
1	Immunotherapy 01/2017
1	Traditional Medicine (Folk Remedies) 01/2017